Dinotefuran is a contact poison and does not require ingestion by the insect to be effective. Dinotefuran binds irreversibly to insect nicotinic receptors and mimics the effects of acetylcholine, resulting in continuous nerve stimulation, incoordination, tremors, and death of the insect.
Pymetrozine Its mode of action in insects has not been precisely determined biochemically, but it may involve effects on neuroregulation or nerve-muscle interaction. Physiologically, it appears to act by preventing these insects from inserting their stylus into the plant tissue.