Chlorantraniliprole activates ryanodine receptors in insects. This activation causes calcium to be released from the internal stores of smooth and striated muscle, resulting in impaired muscle regulation, paralysis, and, eventually, insect death. Chlorantraniliprole has a strong preference for insect ryanodine receptors over mammalian receptors. Pyrethroids are sodium channel modulators that disrupt insect central nervous systems. After contact, the pests are rendered immobile and eventually die. However, while feeding stops almost immediately, death can take up to four days. The host plant is not harmed during this time.